PRIMARY PULMONARY HYPERTENSION (PPH) TREATMENT
Since there is no cure for PPH, the
treatments listed below at best only relieve the symptoms. Relief from these
symptoms however can raise quality of life and raise life
expectancy by several years. Doctors have developed functional
classifications of Primary Pulmonary Hypertension
based on the level of the conditions and symptoms involved. The general
treatments for PPH include: Calcium Channel
blockers that can be used to lower pressure; oxygen
enables the patient to breath easier and lowers pressure; Coumadin (warfarin)
thins the blood and prevents clotting; diuretics or "water pills" relieve
fluid that collects in the ankles and belly area, digoxin slows the heart rate
to improve muscle force.
Thrombosis in situ is believed to be integral to the pathogenesis of PPH.
Anticoagulant therapy has been investigated in patients with PPH and is
associated with improved survival. Although the effectiveness of warfarin
anticoagulation in patients with PPH has never been tested in a randomized,
prospective, long-term trial, based on the known pathogenesis of PPH and the
available data. Experts recommend the use of low-dose warfarin with an
international normalized ratio of 2.0 to 2.5 times control as therapy for PPH.
Calcium Channel Blockers
Vasoconstriction is important in the pathogenesis of PPH in some patients.
Although many drugs have been used for vasodilation in the setting of PPH,
blockers have been the most widely tested class of
drugs for this purpose, and they appear to produce a more consistent reduction
in pulmonary artery pressure and pulmonary vascular resistance that other
vasodilators. Studies show that approximately 25 percent of patients with
PPH will respond to calcium channel blockers). A drug called Flolan
may help many severely ill patients who do not respond to treatment with calcium
channel blockers such as Nifedipine. Flolan imitates the natural prostacyclin
produced by the body to keep blood vessels healthy by removing the build up of
lipids, lowering blood pressure. Most PPH patients do respond to increased
doses of prostaglandin which dilate, or open up, blood vessels in the lungs and
throughout the body. This Flolan-Prostacyclin also appears to prevent blood
clots from forming.
Flolan has been studied in clinical
trials , and is one of only a hand full of FDA approved
drug treatment for PPH. Flolan
is administered intravenously directly into the bloodstream through a surgically
implanted catheter by a portable, battery-operated pump. The pump is worn
attached to a belt around the waist or carried in a small shoulder pack. Since
the drug lasts only 3-5 minutes it must constantly be infused: it is slowly and
continuously pumped into the body through the permanent catheter placed in a
vein in the neck or chest. Additionally Tracleer,
are also being used to treat primary pulmonary hypertension.
Prostacyclin is a metabolite of arachidonic acid that is produced primarily in
the vascular endothelium. Its major pharmacologic actions include potent
vasodilatation of the pulmonary and systemic arterial and venous beds and
inhibition of platelet aggregation. Prostacyclin is administered through a
permanent intravenous catheter and delivered by an ambulatory infusion system.
The delivery system is complex and requires patients to learn the techniques of
sterile preparation, operation of the pump, and care of the intravenous
Diuretics are frequently required to reduce excessive edema in patients with
right heart failure. they are particularly useful when hepatic congestion,
ascites, and edema are present. Digoxin can increase cardiac output and reduce
circulating neurohormones. Patients with hypoxemia, either at rest or with
exercise, should receive supplemental oxygen. Because of increased
cardiovascular stress, pregnancy is generally poorly tolerated by patients with
Heart and Lung Transplantation
Bilateral lung transplantation and single-lung transplantation
have been performed successfully in patients with PPH. The immediate reduction
in pulmonary artery pressure and pulmonary vascular resistance is associated
with an improvement in right ventricular function. Bilateral lung
transplantation is preferred at most centers, because there is greater pulmonary
vascular reserve if the patient sustains rejection or infection. Single lung
transplantation may be preferred in some situations because the operation is
technically less challenging and the waiting time is shorter. As with any type
of organ transplantation, the major long-term morbidity and mortality are
related to the high incidence of rejection and opportunistic infections. In
addition, lung transplantation carries a high risk of the development of
bronchiolitis obliterates. In the era of prostacyclin, lung transplantation
should be considered a treatment of last resort for PPH.
NOTE: Talk with your Doctor and
find out what PPH Treatment Options are available and best for you.
LEGAL OPTIONS FOR PPH PATIENTS
you or a loved one have been diagnosed with Primary Pulmonary Hypertension (PPH),
then you may have a right to file a individual legal action against the
manufacturers of the diet pills or others. Due to the nature of this serious and
devastating disease process, PPH patients are urged to contact an attorney
immediately after he or she has been informed of their Primary Pulmonary
Hypertension diagnosis. Many
important legal issues need to be addressed early after a PPH diagnosis, that
can affect the outcome of the PPH litigation. Call us for a Free Confidential
Consultation. Talk with a Board Certified Personal Injury Trial Lawyer about
your legal rights of a PPH claim against the diet drug industry and others. No
Fees or Expenses Charged unless we make a Recovery for You.
Call Us Toll Free at 1-800-883-9858
or 1-800-468-4878 or E-mail
us your questions on Free
Case Evaluation Form.
If you or a loved one took diet drugs and recently have been given a diagnosis of Primary Pulmonary Hypertension (PPH), idiopathic pulmonary hypertension, pulmonary arterial hypertension, PAH or pulmonary hypertension, then call us for a Free PPH Lawsuit Consultation. Talk to a Personal Injury Trial Lawyer with over 20+ years of product liability trial experience that understands the complications of PPH, legal options for patients with PPH and diet drug related PPH lawsuits and litigation.
Since 1997, we have aggressively represented PPH patients in diet drug lawsuits against the makers of Fen -Phen, Redux and PPH lawsuits against the nutritional supplement industry on herbal ephedrine / ephedra / ma huang PPH lawsuits. Get PPH Lawsuit Help. Talk to a PPH Attorney now. Call Toll Free 1-800-883-9858 or E-mail us.
If you have been diagnosed with PPH then it very important that you talk with an attorney. Mr. Willis is a Board Certified Personal Injury Trial Lawyer, certified by the Texas Board of Legal Specialization since 1988. No Fees or Court Costs or Expenses charged to the client unless we obtain a recovery for you. We never send you a bill for our services! Call us if you have a question.
Call Toll Free
1 800 883 9858
PPH INFO & FAQs
What are the most common PPH Symptoms? Primary Pulmonary Hypertension symptoms may include, Shortness of Breath, Constantly tired, no stamina, chest pains, ankle swelling, water retention, swelling in feet, fainting, bluish lips or skin tones and excessive fatigue after mild to moderate exertion.
How does the Fen Phen Settlement affect a PPH claim or is it too late to file a PPH Lawsuit ? Under the terms of the diet drug class action settlement can PPH victims can still file a separate lawsuit? Call us to discuss your particular facts of your PPH case.
What is PPH? PPH or primary pulmonary hypertension is condition is often fatal and is primarily found in female patients aged 20-40 years old. PPH a rare condition in which the blood pressure in the arteries of the lungs is abnormally high. The cause of PPH - primary pulmonary hypertension is believed to be linked to certain diet drugs, weight loss drugs Pondimin (fenfluramine), diet drug combination Fen-Phen, and Redux (Dexfenfluramine), ephedra, ma huang and other natural ephedrine alkaloids. It is considered a progressive lung disease, often leading to congestive heart failure, respiratory failure, and eventually death. Some PPH patients improve their life expectancy greatly with heart, lung and/or heart lung transplants.
What is the Life Expectancy of a PPH Patient? Sadly, once diagnosed with PPH, the average PPH survival rate is three years. Pregnant women with PPH, have higher rate of maternal mortality. PPH and pregnancy is a bad combination. Drug therapy is a treatment option for a woman with PPH while pregnant. PPH medical treatment options available to people with PPH include anticoagulants, Flolan, Tracleer, diuretics, vasodilators, calcium channel blocking drugs and supplemental oxygen.
The last time I ever took Fen Phen, Pondimin or Redux was back in 1997, but recently I have been diagnosed with PPH or Primary Pulmonary Hypertension. Is it too late to file a PPH claim or lawsuit? How long can I wait till I file a PPH lawsuit? Due to possible running of an applicable Statute of Limitations (filing deadlines for a PPH Lawsuit), it is VERY IMPORTANT that you discuss this with an PPH attorney experienced with clients with PPH and with a proven track record of hard work and dedication to his clients. In some states, the PPH victim may only have up to ONE YEAR to file a PPH lawsuit or litigation from the date of the diagnosis or injury. Filing deadlines for PPH claims in other states may be longer.
pulmonary hypertension is so often fatal.
Diabetes Drug Avandia & PPH
St. John's Wort and PPH / Primary Pulmonary Hypertension
Avandia and PPH - Primary Pulmonary Hypertension
Unexplained Pulmonary Hypertension